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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA1 All Species: 22.12
Human Site: T120 Identified Species: 44.24
UniProt: O95477 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95477 NP_005493.2 2261 254286 T120 L L Y S Q K D T S M K D M R K
Chimpanzee Pan troglodytes XP_001138040 2261 254230 T120 L L Y S Q K D T S M K D M R K
Rhesus Macaque Macaca mulatta XP_001106713 1081 120445
Dog Lupus familis XP_538773 2261 253895 T120 L L Y S Q K D T S M K D I H E
Cat Felis silvestris
Mouse Mus musculus P41233 2261 253955 T120 L L Y S Q R D T S I K D M H K
Rat Rattus norvegicus Q7TNJ2 2170 237702 D120 L G G H S T Q D M L A A L G K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516009 2266 254238 T120 L L Y S Q K D T S M R D I Q K
Chicken Gallus gallus NP_989476 2260 254054 T120 L L Y S Q Q D T S I K D V Q K
Frog Xenopus laevis NP_001089022 2363 267334 H120 L L E K P E I H H L S R M W K
Zebra Danio Brachydanio rerio XP_683123 2330 265308 L120 L F N D T E F L Q L G R L W R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 47 94.9 N.A. 95 50.8 N.A. 89.1 85.4 49.8 51.1 N.A. N.A. N.A. 24.9 N.A.
Protein Similarity: 100 99.7 47.5 97.6 N.A. 97.3 67.4 N.A. 94.6 92.6 66.8 67.8 N.A. N.A. N.A. 43 N.A.
P-Site Identity: 100 100 0 80 N.A. 80 13.3 N.A. 80 73.3 26.6 6.6 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 100 0 93.3 N.A. 93.3 26.6 N.A. 100 100 40 33.3 N.A. N.A. N.A. 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 27.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.8 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 0 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 9 0 0 50 9 0 0 0 50 0 0 0 % D
% Glu: 0 0 9 0 0 17 0 0 0 0 0 0 0 0 9 % E
% Phe: 0 9 0 0 0 0 9 0 0 0 0 0 0 0 0 % F
% Gly: 0 9 9 0 0 0 0 0 0 0 9 0 0 9 0 % G
% His: 0 0 0 9 0 0 0 9 9 0 0 0 0 17 0 % H
% Ile: 0 0 0 0 0 0 9 0 0 17 0 0 17 0 0 % I
% Lys: 0 0 0 9 0 34 0 0 0 0 42 0 0 0 59 % K
% Leu: 75 59 0 0 0 0 0 9 0 25 0 0 17 0 0 % L
% Met: 0 0 0 0 0 0 0 0 9 34 0 0 34 0 0 % M
% Asn: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 50 9 9 0 9 0 0 0 0 17 0 % Q
% Arg: 0 0 0 0 0 9 0 0 0 0 9 17 0 17 9 % R
% Ser: 0 0 0 50 9 0 0 0 50 0 9 0 0 0 0 % S
% Thr: 0 0 0 0 9 9 0 50 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 17 0 % W
% Tyr: 0 0 50 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _